CNS Trial Execution Case Study
Optimizing Phase III CNS Trial Execution Using Real-World Expert Intelligence
A biopharma company faced delays in a Phase III CNS trial due to low patient enrollment and retention challenges.
The Situation
A biopharma company faced delays in a Phase III CNS trial due to low patient enrollment and retention challenges.
The Challenge
- Misalignment between trial design and real-world patient pathways
- Inefficient site selection
- High dropout risk
Our Approach
ApoInsights (Strategic Intelligence Network)
Activated neurologists and clinical investigators across key regions to:
- Validate patient eligibility criteria
- Identify real-world recruitment barriers
- Recommend high-performing trial geographies
ApoKynex
- Structured insights into actionable trial optimization strategies
- Integrated historical trial benchmarking with expert validation
- Delivered execution-ready recommendations
Key Insight
Trial inefficiencies were driven by disconnect between protocol design and real-world clinical practice.
Business Impact
- Improved recruitment efficiency by 35%
- Reduced delays by 4–6 months
- Increased probability of trial success
Strategic Outcome
From protocol-driven design to real-world aligned execution.
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